Hydrocortisone Cream Natureplex’s Hydrocortisone Cream is a cortisone based medication used for the temporary relief of minor skin irritations, itching, and rashes caused by eczema, insect bites, poison ivy, poison oak, poison sumac, soaps, detergents, cosmetics, and jewelry. Hydrocortisone may be used to relieve the itching, redness, dryness, crusting, scaling, inflammation, and discomfort of various skin conditions.